Derek Draper, 53, fell ill in March 2020 after contracting coronavirus and has required a long recovery in intensive care, during which he was placed in a coma.
After more than a year in hospital, he was considered well enough to return to his North London home in April.
The 54-year-old former political adviser is now free of the virus, but has suffered long-lasting damage to his organs and requires care at home.
The Good Morning Britain presenter said her husband, Derek Draper, experiences “a kind of heartbreak” every day.
Kate Garraway opens up on loneliness
Garraway, also 54, told The Sun that she often feels “really lonely” while caring for her husband, and watching him confront his own reality.
“It’s like there’s both grief and hope in the same moment,” she said.
“There are flashes of the old Derek and then he disappears again, and you’re left just feeling really lonely.
“Derek dreams about the ‘before’, and every morning it’s just so, so awful seeing him wake up, and the realisation of where he is.
“There’s a kind of heartbreak in his eyes, every single morning. You can just see it.”
Garraway said that her husband used to be a big eater, and his now lack of appetite left her feeling like she was “living with a stranger”.
In ITV’s Kate Garraway: Caring for Derek, airing on February 22, viewers will see the family’s journey as Draper arrives home from hospital in April 2021.
The film is a follow-up to 2021’s Finding Derek, which showed how the family were coping as Draper was critically ill in hospital with Covid-19.